Oxygen Equilibria of Hemoglobin A2 and Hemoglobin Lepore*

Hemoglobin-oxygen equilibria: retrospective and phenomenological perspective.

The origin of the concept of a molecular complex between oxygen and hemoglobin can be traced to Stokes, a century and a half ago. Subsequently, physicochemical concepts of equilibria provided a path to quantitative formulations of these ligand-receptor interactions. Then, it took a quarter of a century before a proper format was prepared in terms of four stoichiometric equilibria and their asso...

Hemoglobin Lepore,,,. in Two Iranian Families

L EPORE HEMOGLOBINS are the result of unequal crossing over between structural genes coding for #{244} and f3 polypeptide chains of human hemoglobin during melosis. The abnormal polypeptide chain #{244} 3 produced after this crossing over has part of the 5 chain at its N terminus, and the remaining part is similar to the i chain.’ The point of fusion of the two polypeptide chains and the propor...

Erythrocytosis associated with hemoglobin Rainier: oxygen equilibria and marrow regulation.

Hemoglobin Rainier (beta(145) tyrosine-->histidine) is an abnormal hemoglobin associated with increased oxygen affinity, decreased heme-heme interaction, presence of a Bohr effect, and erythrocytosis, but without obvious clinical sequelae. Regulation of erythropoiesis was studied in affected members of families having either hemoglobin Rainier or Yakima, abnormal hemoglobins associated with ery...

Glycosylated hemoglobin A2 components.

Partially purified hemoglobin A2 has been examined for the existence of glycosylated components by isoelectric focusing and by acid agar gel electrophoresis. Bands analogous to the glycohemoglobin derivatives of hemoglobin A, hemoglobin-A1.a.b.c, were readily detected. Evidence that these minor bands are in fact glycohemoglobins was obtained by showing that 14C-glucose bound to hemoglobin A2 mo...

Studies on Hemoglobin Biosynthesis: Asynchronous Synthesis of Hemoglobin a and Hemoglobin A2 by Erythrocyte Precursors.